Inventing a breath test to detect diseases

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  Last updated October 25, 2019 at 3:31 pm

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A breath test that could diagnose 22 different diseases, including cancer, is one stop closer thanks to an Australian scientist.


noushin nasiri_breath test_medical technology

Dr Noushin Nasiri’s breath test could replace invasive medical tests. Credit: Macquarie University.


Diabetes, asthma and some lung cancers could be detected in a radical new way, thanks to a new invention developed by materials scientist Dr Noushin Nasiri.


And the Macquarie University researcher thinks the breath test could be extended to detect other diseases including other cancers.


Her invention can rapidly analyse a person’s breath and detect biomarkers that can so far potentially identify the presence of 22 different diseases.


The new device comprises specially-designed nanomaterials organised into an array of tiny sensors. The nanosensors collect information about what they detect and wirelessly transmit readings to a computer which analyses the data and displays a result.


Dr Nasiri hopes it could be further developed to transmit data to a smartphone. However that would require the development of a complex app, she adds.


How sensors detect biomarkers


“We all know that our breath has evidence of last night’s garlic or maybe the wine you had at lunch,” says Dr Nasiri.


Human breath contains nitrogen, oxygen, carbon dioxide and water vapour, plus a tiny fraction – less than one per cent – of thousands of other gases in very small concentrations,” she says. “There’s evidence that certain combinations of molecules among those gases can indicate particular disease states.”


breath test_police breathalyser_breathalyser

Police breathalysers are the best known example of detecting substances on breath. Credit: Liam McBurney/PA Images via Getty Images


The idea of breath analysis isn’t new. Police breathalysers are the best-known example of detecting substances in our breath, first hitting the streets in 1954. The concentration of alcohol in the breath is about 2,300 times weaker than alcohol in the blood – but even that tiny amount is comparatively easy to detect, says Dr Nasiri.


“Various disease states will leave only very small amounts of a biomarker, often a few parts per billion,” she says. Dogs and even bees have been trained to detect certain diseases based on those tiny amounts of compounds in human breath. However translating that ability into technology for these low concentrations has not been easy.


Nanosensors of remarkable sensitivity


That’s where engineered nanomaterials come in. These are particles of different substances often around one billionth of a centimetre in size. At that molecular scale, their properties can be manipulated to react to the presence of certain compounds or certain radiation types.


Dr Nasiri has developed a material that comprises a spongelike film of billions of nanoparticles made up of zinc, nickel and other elements. Each nanoparticle has a diameter of just a few atoms.


“The sensor has a chemical reaction on its surface when it detects certain biomarkers in your breath,” she says. “My sensor is extremely spongy and has a huge surface area. It has a much greater chance of detecting a tiny concentration of chemical within a breath than a non-nano sensor could do.”


Diabetes detection and management potential


Dr Nasiri’s breathalyser can show when a person has diabetes – but even better, it can also show when glucose levels are awry.


Diabetes occurs when your body doesn’t effectively use insulin to control blood glucose levels. Those with Type 1 diabetes do not produce insulin and must take it each day to stay alive, and monitoring their blood glucose levels is critical. Many type 2 diabetics have similar challenges, says Associate Professor Bernard Champion, an endocrinologist from Macquarie University.


Without enough insulin, the body can’t convert blood glucose into energy and instead burns fat and muscle stores, converting these into ketones. But, high levels of ketones in the blood can cause ketoacidosis, which can put someone into a coma and even kill them.


The next step in a history of breath testing


Professor Champion says that there’s a long tradition of using the breath as an indicator in the disease. “Before we had reliable blood tests, physicians would sometimes smell the breath of a person with diabetes – a fruity nail polish smell indicated ketoacidosis,” he says.


Most diabetes patients regularly check their blood sugar levels with a finger-prick blood test. There are various other non-invasive monitoring systems around like flash and continuous skin-sensors with insulin pumps, but these tend to be expensive and don’t completely replace blood tests, Champion says.


“A non-invasive breath test that is inexpensive and very accurate, could make a real difference to people living with diabetes, particularly for some children who find the blood tests can be traumatic,” he says.


Depending on its accuracy and cost, Champion says that a simple and cheap ‘breathalyser’ type test could also be a real game-changer in diagnosing the growing incidence of Type 2 diabetes.


“Current population screening guidelines recommend testing all at-risk adults over forty every three years, but testing happens with only a small fraction of eligible people,” he says.


Half of people with Type 2 diabetes undiagnosed


About half of all adults who currently have Type 2 diabetes are thought to be undiagnosed, he adds. “Often they have it for three to five years before it gets picked up, and by that time there’s more likely to be underlying damage,” he says.


Nearly 18 per cent of Australian adults could be ‘pre-diabetic,’ meaning that their insulin production is compromised – and studies suggest that without intervention five to ten per cent of these could progress to full Type 2 diabetes each year.


“Early intervention once we identify pre-diabetes can encourage important lifestyle modifications that can avert progression into full diabetes,” Professor Champion says.


noushin nasiri_breath test_medical technology

Dr Noushin Nasiri. Credit: Macquarie University.


“With a simpler, more widely accessible and cost-effective, diagnostic intervention, there’s the potential to make big inroads in identifying people before they need to start using medication or become major consumers of the health care system resources,” he says.


Lung Cancer and early detection


One of the more exciting potential applications of the sensor is in the diagnosing certain lung cancers. Lung cancer remains the leading cause of cancer death in Australia, responsible for around one in five cancer deaths. The current five-year survival rate is around 17 per cent.


Symptoms of lung cancer can be vague or even absent, so the disease is often not discovered until it has spread to other parts of the body and is found via during an XRay or CT scan performed to test for another condition. Around three-quarters of patients aren’t diagnosed until the disease has advanced to Stage III or IV.


Studies have shown that early diagnosis of non-small cell lung cancer followed by surgery is linked to five year survival rates around 70 per cent.


As with diabetes, there’s great clinical potential for a breath test that is simple and cheap and widely available to make a big difference in early diagnosis and to then markedly reduce the cost and improve the effectiveness of treatment for many types of lung cancer.


Breath test and asthma


For the 2.7 million Australians with the chronic lung condition asthma, the device could also offer a more accurate way to monitor allergic response. Patients who have allergic asthma can have inflammation of their lungs for some time before their breathing is affected. However, with earlier intervention of inhaled steroids, less medication would have a much greater impact.


There are already some specialist tests to measure exhaled nitric oxide, but these are expensive and used only by specialists, Dr Nasiri says.


Commercial potential


Over the past year, Dr Nasiri has worked with other researchers at ANU, UTS, QUT and UWA to develop and test different gas sensing materials, and has made changes to her own materials to increase the sensitivity of the breathalyser tenfold.


Her technology can now detect compounds at a rate of two parts per billion. She has also finessed the device so that it is accurate at room temperature, so it will be cheaper to make and easier to use than her earlier models.


Dr Nasiri is now in discussion with potential industry partners to commercialise the invention and anticipates we could see a working model within five years.


This article was originally published by The Lighthouse


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Inventing a breath test to detect diseases




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