Gut bacteria can negatively influence our blood sugar levels

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  Last updated September 20, 2019 at 2:20 pm


Our understanding of gut bacteria keeps expanding, it might negatively influence our blood sugar levels too.

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A world-first study reveals that gut bacteria plays a role in our blood sugar levels. Credit: Flinders University

Why This Matters: Happy gut bacteria, happy body.

Millions of people around the world experience serious blood sugar problems which can cause diabetes. Now, a world first study is revealing how gut bacteria impact the normally feel good hormone serotonin to negatively influence blood sugar levels.

Serotonin, a neurotransmitter in the brain, is nicknamed the ‘happy hormone’ and is normally linked with regulating sleep, well-being and metabolism. But the gut actually produces 95 per cent of it, and not in the happy form like we know about in the brain.

In a study published in the journal Proceedings of the National Academy of Sciences (PNAS), a team of researchers from Flinders University, SAHMRI, and McMaster University in Canada show exactly how bacteria living in the guts of mice, the microbiome, communicate with cells producing serotonin to influence blood sugar levels in the host body.

Gut bacteria impacts our metabolism

Damien Keating, from Flinders University, says this study sheds light on the unanswered question about exactly how bacteria in the microbiome communicate to control glucose levels in the metabolism.

Deeper: Obesity trigger identified within the human gut

“We found that the microbiome worsens our metabolism by signalling to cells in the gut that produce serotonin. They drive up serotonin levels, which we previously showed to be increased in obese humans, and this rise in blood serotonin causes significant metabolic problems.”

“The next step will be to understand exactly which bacteria do this, and how, in the hope that this could lead to new approaches to regulating blood sugar levels in humans,” says Keating

Understanding gut bacteria could lead to improved treatments

This study is the first to show how the microbiome, the bacteria that lives in the gut, effectively communicate with an organism to impact the hosts metabolism.

If researchers can better understand which bacteria cause the signals to produce serotonin in the gut, treatments could one day be developed to reduce blood sugar levels, and this is a first step towards better understanding this process.

“This is an exciting revelation that can one day have direct implications for human health disorders such as diabetes, but much more research like this is required in the years to come.”

Read the full report here.

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